BDBM362836 5-(trans-4-Aminocyclohexyl)-N-butyl-8-[(cyclohexylamino)methyl]-5,6-dihydropyrimido [4,5-c]isoquinolin-3-amine::US9840503, Example 9

SMILES CCCCNc1ncc-2c(n1)N(Cc1cc(CNC3CCCCC3)ccc-21)[C@H]1CC[C@H](N)CC1

InChI Key InChIKey=OLMVGMOLDSQCPI-HCGLCNNCSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 362836   

TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM362836(5-(trans-4-Aminocyclohexyl)-N-butyl-8-[(cyclohexyl...)
Affinity DataIC50: <100nMAssay Description:The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM362836(5-(trans-4-Aminocyclohexyl)-N-butyl-8-[(cyclohexyl...)
Affinity DataIC50: <100nMAssay Description:The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM362836(5-(trans-4-Aminocyclohexyl)-N-butyl-8-[(cyclohexyl...)
Affinity DataIC50: <100nMAssay Description:The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent