BDBM363414 (R)-2-((2-((5-cyanopyridin-3-yl)methoxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)-3-hydroxypropanoic acid::US9850225, Example 1327

SMILES Cc1c(COc2ccc(CN[C@H](CO)C(O)=O)c(OCc3cncc(c3)C#N)c2)cccc1-c1ccccc1

InChI Key InChIKey=NBAJSHKXFFMTLV-GDLZYMKVSA-N

Data  1 IC50  1 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 363414   

TargetProgrammed cell death 1 ligand 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM363414((R)-2-((2-((5-cyanopyridin-3-yl)methoxy)-4-((2-met...)
Affinity DataIC50:  5.30nMAssay Description:The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProgrammed cell death 1 ligand/protein 1(Homo sapiens)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM363414((R)-2-((2-((5-cyanopyridin-3-yl)methoxy)-4-((2-met...)
Affinity DataEC50: >3.00E+4nMAssay Description:Inhibition of human PDL1 expressed in CHO-K1 cells co-expressing aAPC assessed as reduction in PDL1 interaction with human PD1 expressed in Jurkat T ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProgrammed cell death 1 ligand 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM363414((R)-2-((2-((5-cyanopyridin-3-yl)methoxy)-4-((2-met...)
Affinity DataKd:  1.10nMAssay Description:Binding affinity to FC-tagged human PDL1 by SPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed