BDBM36527 1,6-dimethyl-3-phenyl-1H,5H,6H,7H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione, 10::US9073941, 601

SMILES Cn1nc(nc2c1nc(=O)n(C)c2=O)-c1ccccc1

InChI Key InChIKey=SFOMBJIIZPCRJH-UHFFFAOYSA-N

Data  4 IC50  2 Kd  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 36527   

TargetTyrosyl-DNA phosphodiesterase 2(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM36527(1,6-dimethyl-3-phenyl-1H,5H,6H,7H-pyrimido[5,4-e][...)
Affinity DataEC50:  780nMAssay Description:Inhibition of TDP2 (unknown origin) using 4-nitrophenyl phenylphosphonate as substrate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM36527(1,6-dimethyl-3-phenyl-1H,5H,6H,7H-pyrimido[5,4-e][...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of APE-1 (unknown origin) using double-stranded AP-site containing DNA as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Yale University

LigandPNGBDBM36527(1,6-dimethyl-3-phenyl-1H,5H,6H,7H-pyrimido[5,4-e][...)
Affinity DataKd:  585nMAssay Description:AlphaScreen technology based high-throughput (ALPHA) assay is used to identify inhibitors of Hsp90-TPR2A interaction.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4C(Homo sapiens (Human))
Fidelta

Curated by ChEMBL
LigandPNGBDBM36527(1,6-dimethyl-3-phenyl-1H,5H,6H,7H-pyrimido[5,4-e][...)
Affinity DataIC50:  130nMAssay Description:Inhibition of KDM4C (unknown origin) using methylated H3 peptide as substrate by chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Yale University

LigandPNGBDBM36527(1,6-dimethyl-3-phenyl-1H,5H,6H,7H-pyrimido[5,4-e][...)
Affinity DataEC50:  690nMT: 2°CAssay Description:Cell assay using BT474, SKBR3 and MCF-12F cell lines measured by WST-1 colorimetric cell proliferation assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrolipoyl dehydrogenase(Mycobacterium tuberculosis)
Academia Sinica

US Patent
LigandPNGBDBM36527(1,6-dimethyl-3-phenyl-1H,5H,6H,7H-pyrimido[5,4-e][...)
Affinity DataIC50: <40nMpH: 7.0Assay Description:The assay was performed in a manner similar to that described in Bryk et al., Biochemistry (2010) 49:1616-1627 and modified for an online robotics sc...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM36527(1,6-dimethyl-3-phenyl-1H,5H,6H,7H-pyrimido[5,4-e][...)
Affinity DataIC50: <40nMpH: 7.0Assay Description:Mtb PDH (Lpd+DlaT+AceE) is provided by Dr. Bryk Ruslana. The assay was performed in a manner similar to that described in Bryk et al., Biochemistry (...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Yale University

LigandPNGBDBM36527(1,6-dimethyl-3-phenyl-1H,5H,6H,7H-pyrimido[5,4-e][...)
Affinity DataKd:  1.00E+3nMpH: 8.0Assay Description:A fluorescence polarization (FP) assay monitor the fluorescein-labeled C-terminal Hsp90 peptide-TPRA interaction. FP assay will also confirm binding...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed