BDBM36528 3-benzyl-1-ethyl-6-methyl-1H,5H,6H,7H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione, 13

SMILES CCn1nc(Cc2ccccc2)nc2c1nc(=O)n(C)c2=O

InChI Key InChIKey=RMJZNJDSCOIRHY-UHFFFAOYSA-N

Data  2 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 36528   

TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Yale University

LigandPNGBDBM36528(3-benzyl-1-ethyl-6-methyl-1H,5H,6H,7H-pyrimido[5,4...)
Affinity DataKd:  182nMAssay Description:AlphaScreen technology based high-throughput (ALPHA) assay is used to identify inhibitors of Hsp90-TPR2A interaction.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Yale University

LigandPNGBDBM36528(3-benzyl-1-ethyl-6-methyl-1H,5H,6H,7H-pyrimido[5,4...)
Affinity DataEC50:  4.27E+3nMT: 2°CAssay Description:Cell assay using BT474, SKBR3 and MCF-12F cell lines measured by WST-1 colorimetric cell proliferation assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Yale University

LigandPNGBDBM36528(3-benzyl-1-ethyl-6-methyl-1H,5H,6H,7H-pyrimido[5,4...)
Affinity DataKd:  566nMpH: 8.0Assay Description:A fluorescence polarization (FP) assay monitor the fluorescein-labeled C-terminal Hsp90 peptide-TPRA interaction. FP assay will also confirm binding...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed