BDBM368049 4-(methylsulfonyl)-4′-(piperidin-4-yl)-2-(1H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US10227331, Example 236

SMILES CS(=O)(=O)c1ccc(-c2ccc(cc2)C2CCNCC2)c(-c2nnn[nH]2)c1S(N)(=O)=O

InChI Key InChIKey=JGSUJJQLDOGKRS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 368049   

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM368049(4-(methylsulfonyl)-4′-(piperidin-4-yl)-2-(1H...)
Affinity DataIC50:  0.103nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVIM-1 protein(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM368049(4-(methylsulfonyl)-4′-(piperidin-4-yl)-2-(1H...)
Affinity DataIC50:  0.127nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM368049(4-(methylsulfonyl)-4′-(piperidin-4-yl)-2-(1H...)
Affinity DataIC50:  2.12nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent