BDBM369525 US10231967, Example 48-Isomer-1::US9918985, Example 48 Isomer 5

SMILES CC1=N[C@@]2(C[C@H](Oc3ccc(cc23)-c2cccc(Cl)c2)[C@@H]2CCCOC2)N=C1N

InChI Key InChIKey=MWVBEWBNSOHPSD-FHZYATBESA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 369525   

TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM369525(US10231967, Example 48-Isomer-1 | US9918985, Examp...)
Affinity DataIC50:  0.700nMAssay Description:The β-secretase enzyme used in the TR-FRET is prepared as follows: The cDNA for the soluble part of the human β-Secretase (AA 1-AA 460) was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1 [1-460](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM369525(US10231967, Example 48-Isomer-1 | US9918985, Examp...)
Affinity DataIC50:  3.57E+4nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM369525(US10231967, Example 48-Isomer-1 | US9918985, Examp...)
Affinity DataIC50:  20nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent