BDBM370266 BDBM467161::US10233188, Example 153
SMILES CS(=O)(=O)N1CC[C@@H](Nc2ncc3cc(Cl)c(=O)n(C4CCCC4)c3n2)[C@@H](F)C1
InChI Key InChIKey=HEPANBXIOOHVED-LSDHHAIUSA-N
Data 8 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 370266
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1(Homo sapiens (Human))
Therachem Research Medilab
Curated by ChEMBL
Therachem Research Medilab
Curated by ChEMBL
Affinity DataKi: 2.20nMAssay Description:Inhibition of non-phosphorylated CDK6/Cyclin D1 (unknown origin) assessed as reduction in production of ADP using 5-FAM-RRRFRPASPLRGPPK peptide as su...More data for this Ligand-Target Pair
Ligand Info
Affinity DataKi: 2.23nMAssay Description:The purpose of the CDK6/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitor...More data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
Ligand Info
Affinity DataKi: 2.23nMAssay Description:The purpose of the CDK6/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitor...More data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
Ligand Info
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1 [L188C](Homo sapiens (Human))
Pfizer
US Patent
Pfizer
US Patent
Affinity DataKi: 2.23nMAssay Description:The purpose of the CDK6/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitor...More data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
Ligand Info
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Therachem Research Medilab
Curated by ChEMBL
Therachem Research Medilab
Curated by ChEMBL
Affinity DataKi: 63nMAssay Description:Inhibition of recombinant full length wild-type phosphorylated CDK2/Cyclin E1 (unknown origin) expressed in baculovirus expression system assessed as...More data for this Ligand-Target Pair
Ligand Info
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Therachem Research Medilab
Curated by ChEMBL
Therachem Research Medilab
Curated by ChEMBL
Affinity DataKi: 63.2nMAssay Description:The purpose of the CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a flu...More data for this Ligand-Target Pair
Ligand Info
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Therachem Research Medilab
Curated by ChEMBL
Therachem Research Medilab
Curated by ChEMBL
Affinity DataKi: 63.2nMAssay Description:The mobility shift assay electrophoretically separates the fluorescently labeled peptides (substrate and phosphorylated product) following the kinase...More data for this Ligand-Target Pair
Ligand Info
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Therachem Research Medilab
Curated by ChEMBL
Therachem Research Medilab
Curated by ChEMBL
Affinity DataKi: 63.2nMAssay Description:The purpose of the CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a flu...More data for this Ligand-Target Pair
Ligand Info