BDBM370489 1-(4,4-difluorocyclohexyl)-2-(5H-imidazo[5,1- a]isoindol-5-yl)ethanol;::US10233190, Example 1407
SMILES OC(CC1c2ccccc2-c2cncn12)C1CCC(F)(F)CC1
InChI Key InChIKey=BBYFCKZHLMMOBN-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 370489
Affinity DataIC50: <1.00E+3nMAssay Description:The IC50 values for each compound were determined by testing the activity of IDO in a mixture containing 50 mM potassium phosphate buffer at pH 6.5; ...More data for this Ligand-Target Pair
Affinity DataIC50: 46nMAssay Description:Inhibition of purified human IDO1 using L-tryptophan as substrate preincubated for 5 mins followed by substrate addition and measured after 15 mins b...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Newlink Genetics
Curated by ChEMBL
Newlink Genetics
Curated by ChEMBL
Affinity DataEC50: 1.32E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Affinity DataIC50: 4.10E+4nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using midazolam as substrateMore data for this Ligand-Target Pair
Affinity DataEC50: 79nMAssay Description:Inhibition of recombinant human IDO1 expressed in T-REx-293 cells assessed as reduction in kynurenine level measured after 16 hrsMore data for this Ligand-Target Pair