BDBM371610 US11896597, Compound 2
SMILES CCC1(CC)CC(CCN2CCC(CC2)C(O)(c2ccccc2)c2ccccc2)OC1=O
InChI Key InChIKey=OPJQDMOEJWGHBK-UHFFFAOYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 371610
TargetEpidermal growth factor receptor [1-773,'NPH',774-1210](Homo sapiens (Human))
Dizal (Jiangsu) Pharmaceutical Co.
US Patent
Dizal (Jiangsu) Pharmaceutical Co.
US Patent
Affinity DataIC50: 19.7nMAssay Description:The inhibition activity and the selectivity of the compounds against mutant EGFR and WT EGFR were assessed by using WT EGFR cell line A-431 (American...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [1-769,'ASV',770-1210](Homo sapiens (Human))
Dizal (Jiangsu) Pharmaceutical Co.
US Patent
Dizal (Jiangsu) Pharmaceutical Co.
US Patent
Affinity DataIC50: 13.4nMAssay Description:The inhibition activity and the selectivity of the compounds against mutant EGFR and WT EGFR were assessed by using WT EGFR cell line A-431 (American...More data for this Ligand-Target Pair
Affinity DataIC50: 21.3nMAssay Description:The inhibition activity and the selectivity of the compounds against mutant EGFR and WT EGFR were assessed by using WT EGFR cell line A-431 (American...More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2 [1-775,'YVMA',776-1255](Homo sapiens (Human))
Dizal (Jiangsu) Pharmaceutical Co.
US Patent
Dizal (Jiangsu) Pharmaceutical Co.
US Patent
Affinity DataIC50: 4.60nMAssay Description:The inhibition activity and the selectivity of the compounds against mutant EGFR and WT EGFR were assessed by using WT EGFR cell line A-431 (American...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Dizal (Jiangsu) Pharmaceutical Co.
US Patent
Dizal (Jiangsu) Pharmaceutical Co.
US Patent
Affinity DataIC50: 0.5nMAssay Description:The inhibition activity and the selectivity of the compounds against mutant EGFR and WT EGFR were assessed by using WT EGFR cell line A-431 (American...More data for this Ligand-Target Pair