BDBM372973 US10576087, Compound 2.3b::US9895376, Compound 2.3a

SMILES Clc1cc2nc([nH]c2cc1Cl)[C@H]1[C@@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@H]12

InChI Key

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 372973   

TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM372973(US10576087, Compound 2.3b | US9895376, Compound 2....)
Affinity DataIC50:  11nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM372973(US10576087, Compound 2.3b | US9895376, Compound 2....)
Affinity DataIC50:  4nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM372973(US10576087, Compound 2.3b | US9895376, Compound 2....)
Affinity DataIC50:  32nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM372973(US10576087, Compound 2.3b | US9895376, Compound 2....)
Affinity DataIC50:  3nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent