BDBM372994 US10597366, Compound 74::US9896418, Compound 74

SMILES OCc1c(Br)c(Oc2cc(F)cc(Cl)c2)ccc1S(=O)(=O)C(F)F

InChI Key InChIKey=GREQBABHNZHCOV-UHFFFAOYSA-N

Data  2 IC50  4 EC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 372994   

TargetVascular endothelial growth factor A(Homo sapiens (Human))
Peloton Therapeutics

US Patent
LigandPNGBDBM372994(US10597366, Compound 74 | US9896418, Compound 74)
Affinity DataEC50:  320nMAssay Description:Four hours later, serial dilutions of 10× compound stocks were made in growth medium from 500×DMSO stocks, and 20 μL of those 10× stocks were ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetVascular endothelial growth factor A(Homo sapiens (Human))
Peloton Therapeutics

US Patent
LigandPNGBDBM372994(US10597366, Compound 74 | US9896418, Compound 74)
Affinity DataEC50:  320nMAssay Description:About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetVascular endothelial growth factor A(Homo sapiens (Human))
Peloton Therapeutics

US Patent
LigandPNGBDBM372994(US10597366, Compound 74 | US9896418, Compound 74)
Affinity DataEC50:  320nMAssay Description:VEGF: Four hours later, serial dilutions of 10x compound stocks were made in growth medium from 500xDMSO stocks, and 20 uL of those 10x stocks were a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetEndothelial PAS domain-containing protein 1(Homo sapiens (Human))
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM372994(US10597366, Compound 74 | US9896418, Compound 74)
Affinity DataEC50:  330nMAssay Description:Antagonist activity at HIF-2alpha in human 786-O cells co-expressing HIF responsive element after 24 hrs by ONE-Glo luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetEndothelial PAS domain-containing protein 1(Homo sapiens (Human))
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM372994(US10597366, Compound 74 | US9896418, Compound 74)
Affinity DataIC50:  150nMAssay Description:HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetEndothelial PAS domain-containing protein 1(Homo sapiens (Human))
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM372994(US10597366, Compound 74 | US9896418, Compound 74)
Affinity DataIC50:  55nMAssay Description:Binding affinity to His-tagged HIF-2alpha PAS-B domain (unknown origin) after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB