BDBM373133 US9896452, Example 75::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone

SMILES C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccc(F)cc1

InChI Key InChIKey=BPQDADCPUWZLIG-FZKQIMNGSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 373133   

TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Eolas Therapeutics

US Patent
LigandPNGBDBM373133(US9896452, Example 75 | rac-((2S,3R)-3-methyl-2-((...)
Affinity DataIC50:  3nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO-OX1 or CHO-OX2 cells are seeded into black-walled clear-base 384-well plates (Costar) at a density of 20,00...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Eolas Therapeutics

US Patent
LigandPNGBDBM373133(US9896452, Example 75 | rac-((2S,3R)-3-methyl-2-((...)
Affinity DataIC50:  3.30E+3nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO-OX1 or CHO-OX2 cells are seeded into black-walled clear-base 384-well plates (Costar) at a density of 20,00...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Eolas Therapeutics

US Patent
LigandPNGBDBM373133(US9896452, Example 75 | rac-((2S,3R)-3-methyl-2-((...)
Affinity DataIC50:  3nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO-OX1 or CHO-OX2 cells are seeded into black-walled clear-base 384-well plates (Costar) at a density of 20,00...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Eolas Therapeutics

US Patent
LigandPNGBDBM373133(US9896452, Example 75 | rac-((2S,3R)-3-methyl-2-((...)
Affinity DataIC50:  3.28E+3nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO-OX1 or CHO-OX2 cells are seeded into black-walled clear-base 384-well plates (Costar) at a density of 20,00...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent