BDBM374598 3-amino-5-(3-{[(4-tert-butyl-2-fluorophenyl)carbonyl]amino}-2-methylphenyl)-1H-indazole-7-carboxamide::US10246457, Example 7

SMILES Cc1c(NC(=O)c2ccc(cc2F)C(C)(C)C)cccc1-c1cc(C(N)=O)c2[nH]nc(N)c2c1

InChI Key InChIKey=ZRMQIITVCNSMEV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 374598   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM374598(3-amino-5-(3-{[(4-tert-butyl-2-fluorophenyl)carbon...)
Affinity DataIC50:  1.00E+3nMAssay Description:Btk enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (lime-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM374598(3-amino-5-(3-{[(4-tert-butyl-2-fluorophenyl)carbon...)
Affinity DataIC50:  64.5nMAssay Description:Btk enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (lime-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent