BDBM376371 N-(3-(1- methylazetidin-3- ylcarbamoyl) benzyl)-6H- isochromeno [3,4-c]pyridine-::US9914740, VII-9
SMILES CN1CC(C1)NC(=O)c1cccc(CNC(=O)c2ccc-3c(COc4cnccc-34)c2)c1
InChI Key InChIKey=DBKFQGAJZUOGMZ-UHFFFAOYSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 376371
Affinity DataIC50: 0.780nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Affinity DataIC50: 8.90nMAssay Description:Inhibition of ROCK1 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH as substrate by caliper assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.850nMAssay Description:Inhibition of ROCK2 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH as substrate by caliper assayMore data for this Ligand-Target Pair