BDBM376371 N-(3-(1- methylazetidin-3- ylcarbamoyl) benzyl)-6H- isochromeno [3,4-c]pyridine-::US9914740, VII-9

SMILES CN1CC(C1)NC(=O)c1cccc(CNC(=O)c2ccc-3c(COc4cnccc-34)c2)c1

InChI Key InChIKey=DBKFQGAJZUOGMZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 376371   

TargetRho-associated protein kinase 2(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM376371(N-(3-(1- methylazetidin-3- ylcarbamoyl) benzyl)-6H...)
Affinity DataIC50:  0.780nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM376371(N-(3-(1- methylazetidin-3- ylcarbamoyl) benzyl)-6H...)
Affinity DataIC50:  8.90nMAssay Description:Inhibition of ROCK1 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH as substrate by caliper assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM376371(N-(3-(1- methylazetidin-3- ylcarbamoyl) benzyl)-6H...)
Affinity DataIC50:  0.850nMAssay Description:Inhibition of ROCK2 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH as substrate by caliper assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed