BDBM376390 N-(3-(((S)-1-ethylpyrrolidin- 2-yl)methylcarbamoyl) benzyl)-6-methyl-6H- isochromeno[3,4-c] pyridine-8-carboxamide::US9914740, VIII-16
SMILES CCN1CCC[C@H]1CNC(=O)c1cccc(CNC(=O)c2ccc-3c(c2)C(C)Oc2cnccc-32)c1
InChI Key InChIKey=HWVIELIZINHJJY-BVHINDKJSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 376390
Affinity DataIC50: 0.600nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of ROCK1 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH as substrate by caliper assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of ROCK2 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH as substrate by caliper assayMore data for this Ligand-Target Pair