BDBM376393 6-ethyl-N-((R)-1-phenylethyl)- 6H-isochromeno[3,4-c] pyridine-8-carboxamide::US9914740, VIII-19::US9914740, VIII-36

SMILES CCC1Oc2cnccc2-c2ccc(cc12)C(=O)N[C@@H](C)c1ccccc1

InChI Key InChIKey=YXVTWZGVCHWRFB-ZDGMYTEDSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 376393   

TargetRho-associated protein kinase 2(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM376393(6-ethyl-N-((R)-1-phenylethyl)- 6H-isochromeno[3,4-...)
Affinity DataIC50:  1.70nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM376393(6-ethyl-N-((R)-1-phenylethyl)- 6H-isochromeno[3,4-...)
Affinity DataIC50:  4.10nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent