BDBM377746 5-amino-3-[4-(4-chloro-3-methylphenoxy)phenyl]-1-(1-cyanopiperidin-3-yl)-1H-pyrazole-4-carboxamide::US10266513, Example 40::US10815213, Example 40

SMILES Cc1cc(Oc2ccc(cc2)-c2nn(C3CCCN(C3)C#N)c(N)c2C(N)=O)ccc1Cl

InChI Key InChIKey=FEMUUJRZCCAVCD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 377746   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377746(5-amino-3-[4-(4-chloro-3-methylphenoxy)phenyl]-1-(...)
Affinity DataIC50:  1.5nMAssay Description:BTK: TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377746(5-amino-3-[4-(4-chloro-3-methylphenoxy)phenyl]-1-(...)
Affinity DataIC50:  1.5nMAssay Description:TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent