BDBM378887 US10266537, Compound 31

SMILES CN1CCC(CC1)n1nc(C#Cc2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)c2c(N)ncnc12

InChI Key InChIKey=LQSGDXCDNZWTJN-UHFFFAOYSA-N

Data  24 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 378887   

TargetProto-oncogene tyrosine-protein kinase Src [1-530](Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50:  2nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50:  19nMAssay Description:Antagonist potency at cloned recombinant human adenosine A2B receptor transfected in CHO cells by cAMP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50:  5nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50:  22nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50:  19nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Yes(Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50: <1nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50:  3nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50:  12nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50:  12nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEphrin type-A receptor 2(Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50:  18nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEphrin type-B receptor 2(Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50:  10nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEphrin type-B receptor 4(Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50:  11nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50:  251nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpithelial discoidin domain-containing receptor 1(Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50:  4nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50:  74nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50:  203nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50:  127nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50:  18nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50:  396nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50:  600nMAssay Description:Inhibition of human ERG expressed in CHO cells at -80 mV holding potential by automated Qpatch electrophysiological assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))TBA
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50:  2nMAssay Description:Antagonist potency at cloned recombinant human adenosine A2A receptor transfected in CHO cells by cAMP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50:  12nMAssay Description:Antagonist potency against adenosine A2B receptor of guinea pig thoracic aortic smooth muscleMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50:  22nMAssay Description:Antagonist potency against adenosine A2A receptor of Sprague-Dawley rat aortic smooth muscleMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProto-oncogene tyrosine-protein kinase Src [T341M](Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50:  3.73E+3nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent