BDBM379177 2-(5-Bromo-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-yloxy)-N-methylbenzamide::US10266549, Example 171a::US10266549, Example 88::US10774092, Example 171a

SMILES CNC(=O)c1ccccc1Oc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Br

InChI Key InChIKey=NEXGBSJERNQRSV-UHFFFAOYSA-N

Data  14 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 379177   

TargetSerine/threonine-protein kinase ULK1(Homo sapiens (Human))
Salk Institute

US Patent
LigandPNGBDBM379177(2-(5-Bromo-2-(3,4,5-trimethoxyphenylamino)pyrimidi...)
Affinity DataIC50: <200nMAssay Description:Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase ULK1(Homo sapiens (Human))
Salk Institute

US Patent
LigandPNGBDBM379177(2-(5-Bromo-2-(3,4,5-trimethoxyphenylamino)pyrimidi...)
Affinity DataIC50:  108nMAssay Description:Inhibition of GST-tagged ULK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase ULK2(Homo sapiens (Human))
Sichuan Universitt China Hospital

Curated by ChEMBL
LigandPNGBDBM379177(2-(5-Bromo-2-(3,4,5-trimethoxyphenylamino)pyrimidi...)
Affinity DataIC50:  711nMAssay Description:Inhibition of GST-tagged ULK2 (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase ULK1(Homo sapiens (Human))
Salk Institute

US Patent
LigandPNGBDBM379177(2-(5-Bromo-2-(3,4,5-trimethoxyphenylamino)pyrimidi...)
Affinity DataIC50: <200nMAssay Description:Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase ULK2(Homo sapiens (Human))
Sichuan Universitt China Hospital

Curated by ChEMBL
LigandPNGBDBM379177(2-(5-Bromo-2-(3,4,5-trimethoxyphenylamino)pyrimidi...)
Affinity DataIC50:  11nMAssay Description:Inhibition of ULK2 (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase ULK1(Homo sapiens (Human))
Salk Institute

US Patent
LigandPNGBDBM379177(2-(5-Bromo-2-(3,4,5-trimethoxyphenylamino)pyrimidi...)
Affinity DataIC50:  108nMAssay Description:Inhibition of FLAG-tagged ULK1 (unknown origin) expressed in HEK293T cells using GST-labelled Atg101 as substrate in presence of gamma-[32]P-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase ULK1(Homo sapiens (Human))
Salk Institute

US Patent
LigandPNGBDBM379177(2-(5-Bromo-2-(3,4,5-trimethoxyphenylamino)pyrimidi...)
Affinity DataIC50:  108nMAssay Description:Competitive inhibition of ULK1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase ULK1(Homo sapiens (Human))
Salk Institute

US Patent
LigandPNGBDBM379177(2-(5-Bromo-2-(3,4,5-trimethoxyphenylamino)pyrimidi...)
Affinity DataIC50:  130nMAssay Description:Inhibition of recombinant human ULK1 (1-649) expressed in Sf9 cells using myelin basic protein as substrate by ADP-glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase ULK1(Homo sapiens (Human))
Salk Institute

US Patent
LigandPNGBDBM379177(2-(5-Bromo-2-(3,4,5-trimethoxyphenylamino)pyrimidi...)
Affinity DataIC50:  785nMAssay Description:Inhibition of ULK1 (unknown origin) expressed in HEK293T cells incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase ULK2(Homo sapiens (Human))
Sichuan Universitt China Hospital

Curated by ChEMBL
LigandPNGBDBM379177(2-(5-Bromo-2-(3,4,5-trimethoxyphenylamino)pyrimidi...)
Affinity DataIC50:  2.45E+3nMAssay Description:Inhibition of recombinant human ULK2 (1 to 478 residues) expressed in Sf9 cells using myelin basic protein as substrate by ADP-glo assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase ULK2(Homo sapiens (Human))
Sichuan Universitt China Hospital

Curated by ChEMBL
LigandPNGBDBM379177(2-(5-Bromo-2-(3,4,5-trimethoxyphenylamino)pyrimidi...)
Affinity DataIC50:  4.58E+3nMAssay Description:Inhibition of ULK2 (unknown origin) expressed in HEK293T cells incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase ULK1(Homo sapiens (Human))
Salk Institute

US Patent
LigandPNGBDBM379177(2-(5-Bromo-2-(3,4,5-trimethoxyphenylamino)pyrimidi...)
Affinity DataIC50:  108nMAssay Description:Inhibition of ULK1 (unknown origin) by 32P-ATP radio active assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase ULK2(Homo sapiens (Human))
Sichuan Universitt China Hospital

Curated by ChEMBL
LigandPNGBDBM379177(2-(5-Bromo-2-(3,4,5-trimethoxyphenylamino)pyrimidi...)
Affinity DataIC50:  711nMAssay Description:Inhibition of ULK2 (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase ULK1(Homo sapiens (Human))
Salk Institute

US Patent
LigandPNGBDBM379177(2-(5-Bromo-2-(3,4,5-trimethoxyphenylamino)pyrimidi...)
Affinity DataIC50: <200nMAssay Description:ULK1 inhibition assay is a screening assay to identify compounds that inhibit kinase activity of ULK1 using the ULKtide peptide. In some embodiments,...More data for this Ligand-Target Pair
In DepthDetails US Patent