BDBM379445 N4-cyclopropyl-N2-(4-ethyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine::US10266549, Example 344::US10774092, Example 344
SMILES CCN1CCOc2cc(Nc3ncc(c(NC4CC4)n3)C(F)(F)F)cnc12
InChI Key InChIKey=SNXCRQROFBPRPD-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 379445
Affinity DataIC50: <200nMAssay Description:Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...More data for this Ligand-Target Pair
Affinity DataIC50: 1.22E+3nMAssay Description:Inhibition of ULK1 (unknown origin) expressed in HEK293T cells incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Inhibition of recombinant human ULK1 (1-649) expressed in Sf9 cells using myelin basic protein as substrate by ADP-glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: <200nMAssay Description:ULK1 inhibition assay is a screening assay to identify compounds that inhibit kinase activity of ULK1 using the ULKtide peptide. In some embodiments,...More data for this Ligand-Target Pair