BDBM38027 US10093646, Example 8::US10774065, Example 8::US11401259, Example 8

SMILES CC1(CN)CCN(CC1)c1cnc(c(N)n1)-c1cccc(Cl)c1Cl

InChI Key InChIKey=ZPEHRKQVKJECQN-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 38027   

TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM38027(US10093646, Example 8 | US10774065, Example 8 | US...)
Affinity DataIC50:  76nMpH: 7.2 T: 2°CAssay Description:More specifically, the phosphatase reactions were performed at room temperature in 384-well black polystyrene plate, flat bottom, low flange, non-bin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM38027(US10093646, Example 8 | US10774065, Example 8 | US...)
Affinity DataIC50:  76nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM38027(US10093646, Example 8 | US10774065, Example 8 | US...)
Affinity DataIC50:  76nMAssay Description:More specifically, the phosphatase reactions were performed at room temperature in 384-well black polystyrene plate, flat bottom, low flange, non-bin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM38027(US10093646, Example 8 | US10774065, Example 8 | US...)
Affinity DataIC50:  357nMAssay Description:Allosteric inhibition of human SHP2 in human KYSE-520 cells assessed as reduction in ERK1/2 phosphorylation by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM38027(US10093646, Example 8 | US10774065, Example 8 | US...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human ERG by Q-patch assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM38027(US10093646, Example 8 | US10774065, Example 8 | US...)
Affinity DataIC50:  76nMAssay Description:Allosteric inhibition of 6x-histidine tagged human SHP2 (Met1-L525 residues) expressed in Escherichia coli BL21 Star (DE3) using IRS1_pY1172(dPEG8)pY...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed