BDBM380768 (R)-6-(4-chlorophenyl)-5-(3,7-dimethyl-3H-[1,2,3]triazolo[4,5-b]pyridin-5-yl)-1-isopropyl-2-(2-methoxypyridin-3-yl)-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H)-one::US9890166, Example 158

SMILES COc1ncccc1-c1nc2C(=O)N([C@@H](c2n1C(C)C)c1ccc(Cl)cc1)c1cc(C)c2nnn(C)c2n1

InChI Key InChIKey=VQVSQBFKHGXUFK-JOCHJYFZSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 380768   

TargetBromodomain-containing protein 4(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM380768((R)-6-(4-chlorophenyl)-5-(3,7-dimethyl-3H-[1,2,3]t...)
Affinity DataIC50: <11nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCREB-binding protein(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM380768((R)-6-(4-chlorophenyl)-5-(3,7-dimethyl-3H-[1,2,3]t...)
Affinity DataIC50: >3.70E+4nMAssay Description:In order to assess bromodomain selectivity, we set up a binding assay using the bromodomain encoded by the CREBBP gene. Compounds were tested in the ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 3(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM380768((R)-6-(4-chlorophenyl)-5-(3,7-dimethyl-3H-[1,2,3]t...)
Affinity DataIC50: <11nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM380768((R)-6-(4-chlorophenyl)-5-(3,7-dimethyl-3H-[1,2,3]t...)
Affinity DataIC50:  16nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent