BDBM384563 US9932350, 2-15::[(4-{[trans-4- (dimethylamino)cyclohexyl] aminoiquinazolin-6- yl)oxy]acetonitrile

SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(OCC#N)cc12

InChI Key InChIKey=KRUNSLDMJUSBNZ-HDJSIYSDSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 384563   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384563(US9932350, 2-15 | [(4-{[trans-4- (dimethylamino)cy...)
Affinity DataIC50:  12nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent