BDBM386003 2-[4-(7,8-Dihydro-6H-pyrimido[5,4-b][1,4]oxazin-4-yl)-piperazin-1-yl]-2-(4-trifluoromethylphenyl)-ethylamine::US10287300, Compound A10

SMILES NCC(N1CCN(CC1)c1ncnc2NCCOc12)c1ccc(cc1)C(F)(F)F

InChI Key InChIKey=JPMGIALHKNEWPB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 386003   

TargetProline-rich AKT1 substrate 1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM386003(2-[4-(7,8-Dihydro-6H-pyrimido[5,4-b][1,4]oxazin-4-...)
Affinity DataIC50:  300nMAssay Description:A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRibosomal protein S6 kinase beta-1 [T412E](Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM386003(2-[4-(7,8-Dihydro-6H-pyrimido[5,4-b][1,4]oxazin-4-...)
Affinity DataIC50:  750nMAssay Description:P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent