BDBM390795 US9957263, Example 57

SMILES Cn1cc(-c2cc(ccc2Oc2cccc(NS(=O)(=O)c3cccc(c3)C#N)c2)S(C)(=O)=O)c2cc[nH]c2c1=O

InChI Key InChIKey=GXUVQNMQPJKIGB-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 390795   

TargetBromodomain-containing protein 4(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM390795(US9957263, Example 57)
Affinity DataKi:  2.20nMAssay Description:Compound dilution series were prepared in DMSO via a 3-fold serial dilution from 2.5 mM to 42 nM. Compounds were then diluted 6:100 in assay buffer (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM390795(US9957263, Example 57)
Affinity DataKi:  5.30nMAssay Description:Compound dilution series were prepared in DMSO via a 3-fold serial dilution from 2.5 mM to 42 nM. Compounds were then diluted 6:100 in assay buffer (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent