BDBM393363 3-([1,1'-Biphenyl]-4-ylmethoxy)azetidine-1-carbonitrile::US9963444, Example 64

SMILES N#CN1CC(C1)OCc1ccc(cc1)-c1ccccc1

InChI Key InChIKey=ZSTZNGPOKKKVCT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 393363   

TargetN-acylethanolamine-hydrolyzing acid amidase(Homo sapiens (Human))
Northeastern University

US Patent
LigandPNGBDBM393363(3-([1,1'-Biphenyl]-4-ylmethoxy)azetidine-1-carboni...)
Affinity DataIC50:  55nMAssay Description:In order to have an assay method more conducive to high-throughput screening than those published for measuring the NAE hydrolyzing activity of NAAA,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetN-acylethanolamine-hydrolyzing acid amidase(Homo sapiens (Human))
Northeastern University

US Patent
LigandPNGBDBM393363(3-([1,1'-Biphenyl]-4-ylmethoxy)azetidine-1-carboni...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of NAAA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-acylethanolamine-hydrolyzing acid amidase(Homo sapiens (Human))
Northeastern University

US Patent
LigandPNGBDBM393363(3-([1,1'-Biphenyl]-4-ylmethoxy)azetidine-1-carboni...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed