BDBM393376 3-((4'-Fluoro-[1,1'-biphenyl]-4-yl)methoxy)azetidine-1-carbonitrile::US9963444, Example 77

SMILES Fc1ccc(cc1)-c1ccc(COC2CN(C2)C#N)cc1

InChI Key InChIKey=BKJDTTMYPPBQSG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 393376   

TargetN-acylethanolamine-hydrolyzing acid amidase(Homo sapiens (Human))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM393376(3-((4'-Fluoro-[1,1'-biphenyl]-4-yl)methoxy)azetidi...)
Affinity DataIC50:  0.680nMAssay Description:Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetN-acylethanolamine-hydrolyzing acid amidase(Homo sapiens (Human))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM393376(3-((4'-Fluoro-[1,1'-biphenyl]-4-yl)methoxy)azetidi...)
Affinity DataIC50:  55nMAssay Description:In order to have an assay method more conducive to high-throughput screening than those published for measuring the NAE hydrolyzing activity of NAAA,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent