BDBM393397 3-((4-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)benzyl)oxy)-3-phenylazetidine-1-carbonitrile::US9963444, Example 98

SMILES N#CN1CC(C1)(OCc1ccc(cc1)-c1ccc2OCCOc2c1)c1ccccc1

InChI Key InChIKey=DFOHFZNZQQZKIH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 393397   

TargetN-acylethanolamine-hydrolyzing acid amidase(Homo sapiens (Human))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM393397(3-((4-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)benzyl)...)
Affinity DataIC50:  6.10nMAssay Description:Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetN-acylethanolamine-hydrolyzing acid amidase(Homo sapiens (Human))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM393397(3-((4-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)benzyl)...)
Affinity DataIC50:  55nMAssay Description:In order to have an assay method more conducive to high-throughput screening than those published for measuring the NAE hydrolyzing activity of NAAA,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent