BDBM395723 (+/−)-Cis and trans-9-(2-(difluoromethoxy)phenyl)-2-(4-(2-hydroxypropan-2-yl)phenyl)-6,7,8,9-tetrahydropyrido[4′,3′:4,5]imidazo[1,2-b]pyridazin-6-ol::US10308652, Example 4::US10308652, Example 5::US10308652, Example 7

SMILES CC(C)(O)c1ccc(cc1)-c1ccc2nc3[C@@H](O)CN[C@H](c3n2n1)c1ccccc1OC(F)F

InChI Key InChIKey=FZQQHPGRNQKJSY-RXVVDRJESA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 395723   

TargetTumor necrosis factor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM395723((+/−)-Cis and trans-9-(2-(difluoromethoxy)ph...)
Affinity DataIC50: <1.00E+3nMAssay Description:Test compounds serially diluted in DMSO were plated in an assay plate (Labcyte, Cat. #LP-0200) at final concentrations ranging from 0.004 μM to ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM395723((+/−)-Cis and trans-9-(2-(difluoromethoxy)ph...)
Affinity DataIC50:  5.50E+3nMAssay Description:Test compounds serially diluted in DMSO were plated in an assay plate (Labcyte, Cat. #LP-0200) at final concentrations ranging from 0.004 μM to ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM395723((+/−)-Cis and trans-9-(2-(difluoromethoxy)ph...)
Affinity DataIC50:  5.50E+3nMAssay Description:Test compounds serially diluted in DMSO were plated in an assay plate (Labcyte, Cat. #LP-0200) at final concentrations ranging from 0.004 μM to ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent