BDBM402018 5-[[5-[4-[[(2S)-1-ethylpyrrolidin-2-yl]methoxy]-2-methoxy-phenyl]-1H-pyrazol-3-yl]amino]pyrazine-2-carbonitrile hydrochloride::US10010547, Example 128::US10973817, Example 128
SMILES CCN1CCC[C@H]1COc1ccc(-c2cc(Nc3cnc(cn3)C#N)n[nH]2)c(OC)c1
InChI Key InChIKey=OCPXBBPANZDCIQ-INIZCTEOSA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 402018
Affinity DataIC50: 0.0230nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0230nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair