BDBM404532 (R)-N-(1- cyanopyrrolidin- 3-yl)-2-fluoro-4- (2-methyl-3H- pyrrolo[2,3- d]pyrimidin-4- yl)benzamide::US10343992, Example 184::US10689345, Example 184::US11066365, Example 184

SMILES Cc1nc2nccc2c([nH]1)-c1ccc(C(=O)N[C@@H]2CCN(C2)C#N)c(F)c1

InChI Key InChIKey=OFRZTFKFRAQWLW-CYBMUJFWSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 404532   

TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
Missions Therapeutics

US Patent
LigandPNGBDBM404532((R)-N-(1- cyanopyrrolidin- 3-yl)-2-fluoro-4- (2-me...)
Affinity DataIC50: <100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
Missions Therapeutics

US Patent
LigandPNGBDBM404532((R)-N-(1- cyanopyrrolidin- 3-yl)-2-fluoro-4- (2-me...)
Affinity DataIC50: <100nMAssay Description:USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
Missions Therapeutics

US Patent
LigandPNGBDBM404532((R)-N-(1- cyanopyrrolidin- 3-yl)-2-fluoro-4- (2-me...)
Affinity DataIC50: <100nMAssay Description:USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent