BDBM406818 3-fluoro-N-[2-(2-methoxypyrimidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine::US10336761, Example 101

SMILES COc1nccc(n1)-c1nc(Nc2ccncc2F)c2cccn2n1

InChI Key InChIKey=WELLLPRMKHYPPA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 406818   

TargetTGF-beta receptor type-2(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM406818(3-fluoro-N-[2-(2-methoxypyrimidin-4-yl)pyrrolo[2,1...)
Affinity DataIC50:  100nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM406818(3-fluoro-N-[2-(2-methoxypyrimidin-4-yl)pyrrolo[2,1...)
Affinity DataIC50:  530nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent