BDBM407433 (R)-6-(3-cyanopyrrolo[1,2- b]pyridazin-7-yl)-N-(2- fluoro-3-hydroxy-3- methylbutyl)-4-(thiazol-2- ylamino)nicotinamide::US10336762, Compound 375

SMILES CC(C)(O)[C@H](F)CNC(=O)c1cnc(cc1Nc1nccs1)-c1ccc2cc(cnn12)C#N

InChI Key InChIKey=RWOUFWSRZFLGOF-LJQANCHMSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 407433   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM407433((R)-6-(3-cyanopyrrolo[1,2- b]pyridazin-7-yl)-N-(2-...)
Affinity DataIC50:  1nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (GibcoŽ 200 mM L-alanyl-L-glutamine) (10 mM HEPES, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM407433((R)-6-(3-cyanopyrrolo[1,2- b]pyridazin-7-yl)-N-(2-...)
Affinity DataEC50:  110nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (GibcoŽ 200 mM L-alanyl-L-glutamine) (10 mM HEPES, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent