BDBM407446 N-(cyanomethyl)-6-(3- cyanopyrrolo[1,2-b] pyridazin-7-yl)-4- (((1s,3s)-3-hydroxy-3- methylcyclobutyl)amino) nicotinamide::US10336762, Compound 388

SMILES C[C@@]1(O)C[C@@H](C1)Nc1cc(ncc1C(=O)NCC#N)-c1ccc2cc(cnn12)C#N

InChI Key InChIKey=VUYMRQFCHZCKHN-QCKZDCLWSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 407446   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM407446(N-(cyanomethyl)-6-(3- cyanopyrrolo[1,2-b] pyridazi...)
Affinity DataIC50:  1nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (GibcoŽ 200 mM L-alanyl-L-glutamine) (10 mM HEPES, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM407446(N-(cyanomethyl)-6-(3- cyanopyrrolo[1,2-b] pyridazi...)
Affinity DataEC50:  96nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (GibcoŽ 200 mM L-alanyl-L-glutamine) (10 mM HEPES, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent