BDBM407457 (R)-6-(3-cyanopyrrolo[1,2- b]pyridazin-7-yl)-N-(2- fluoro-3-hydroxy-3- methylbutyl)-4-((4-(2- oxooxazolidin-3- yl)bicyclo[2.2.2]octan-1- yl)amino)nicotinamide::US10336762, Compound 399

SMILES CC(C)(O)[C@H](F)CNC(=O)c1cnc(cc1NC12CCC(CC1)(CC2)N1CCOC1=O)-c1ccc2cc(cnn12)C#N

InChI Key InChIKey=TXGGFIUGSSQZBD-WDEPAJCISA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 407457   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM407457((R)-6-(3-cyanopyrrolo[1,2- b]pyridazin-7-yl)-N-(2-...)
Affinity DataIC50: <1nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (GibcoŽ 200 mM L-alanyl-L-glutamine) (10 mM HEPES, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM407457((R)-6-(3-cyanopyrrolo[1,2- b]pyridazin-7-yl)-N-(2-...)
Affinity DataEC50:  8nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (GibcoŽ 200 mM L-alanyl-L-glutamine) (10 mM HEPES, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent