BDBM407464 (R)-6-(3-cyanopyrrolo[1,2- b]pyridazin-7-yl)-4-((4- (cyclopropylcarbamoyl) bicyclo[2.2.2]octan-1- yl)amino)-N-(2-fluoro-3- hydroxy-3-methylbutyl) nicotinamide::US10336762, Compound 406

SMILES CC(C)(O)[C@H](F)CNC(=O)c1cnc(cc1NC12CCC(CC1)(CC2)C(=O)NC1CC1)-c1ccc2cc(cnn12)C#N

InChI Key InChIKey=BWTHDKOAHNXWOR-GXUJUKEASA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 407464   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM407464((R)-6-(3-cyanopyrrolo[1,2- b]pyridazin-7-yl)-4-((4...)
Affinity DataIC50:  1nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (GibcoŽ 200 mM L-alanyl-L-glutamine) (10 mM HEPES, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM407464((R)-6-(3-cyanopyrrolo[1,2- b]pyridazin-7-yl)-4-((4...)
Affinity DataEC50:  33nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (GibcoŽ 200 mM L-alanyl-L-glutamine) (10 mM HEPES, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent