BDBM407877 (R)-4-((1,6-naphthyridin- 2-yl)amino)-6-(3-cyano- pyrrolo[1,2-b]pyridazin-7- yl)-N-(2-fluoro-3-hydroxy- 3-methylbutyl)nicotinamide::US10336762, Compound 821

SMILES CC(C)(O)[C@H](F)CNC(=O)c1cnc(cc1Nc1ccc2cnccc2n1)-c1ccc2cc(cnn12)C#N

InChI Key InChIKey=IURPAFDORQHTES-XMMPIXPASA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 407877   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM407877((R)-4-((1,6-naphthyridin- 2-yl)amino)-6-(3-cyano- ...)
Affinity DataIC50: <1nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (GibcoŽ 200 mM L-alanyl-L-glutamine) (10 mM HEPES, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM407877((R)-4-((1,6-naphthyridin- 2-yl)amino)-6-(3-cyano- ...)
Affinity DataEC50:  51nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (GibcoŽ 200 mM L-alanyl-L-glutamine) (10 mM HEPES, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent