BDBM407889 6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-4-((3- (((R)-2,2-difluorocyclo- propane-1-carboxamido) methyl)bicyclo[1.1.1] pentan-1-yl)amino)-N- ((R)-2-fluoro-3-hydroxy- 3-methylbutyl)nicotinamide::US10336762, Compound 833

SMILES CC(C)(O)[C@H](F)CNC(=O)c1cnc(cc1NC12CC(CNC(=O)C3CC3(F)F)(C1)C2)-c1ccc2cc(cnn12)C#N

InChI Key InChIKey=FHCZTNQBFUTORM-GNZOPSJWSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 407889   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM407889(6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-4-((3- ((...)
Affinity DataIC50:  1nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (GibcoŽ 200 mM L-alanyl-L-glutamine) (10 mM HEPES, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM407889(6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-4-((3- ((...)
Affinity DataEC50:  192nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (GibcoŽ 200 mM L-alanyl-L-glutamine) (10 mM HEPES, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent