BDBM408797 N-[(2,6-difluoro-3-methoxyphenyl)methyl]-3-(methoxymethyl)-1-({4-[(4-methyl-2- oxopyridin-1-yl)methyl]phenyl}methyl)pyrazole-4-carboxamide::US10364238, Example 106::US11001578, Example 106::US11084809, Example 106::US11198691, Example 106

SMILES COCc1nn(Cc2ccc(Cn3ccc(C)cc3=O)cc2)cc1C(=O)NCc1c(F)ccc(OC)c1F

InChI Key InChIKey=BKTJDPOLKWOBHW-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 408797   

TargetKallikrein-1(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM408797(N-[(2,6-difluoro-3-methoxyphenyl)methyl]-3-(methox...)
Affinity DataIC50: >1.00E+4nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM408797(N-[(2,6-difluoro-3-methoxyphenyl)methyl]-3-(methox...)
Affinity DataIC50:  140nMAssay Description:KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25° C. with the fluoroge...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent