BDBM410186 (R)-5-(4,4-difluoro-2-(5-fluoropyridin-3-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile ::US10370379, Compound 3::US11059827, Compound 3

SMILES Fc1cncc(c1)[C@H]1CC(F)(F)CN1c1ccn2ncc(C#N)c2n1

InChI Key InChIKey=RIPMGJDKYGULEO-CYBMUJFWSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 410186   

TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM410186((R)-5-(4,4-difluoro-2-(5-fluoropyridin-3-yl)pyrrol...)
Affinity DataIC50:  300nMAssay Description:In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM410186((R)-5-(4,4-difluoro-2-(5-fluoropyridin-3-yl)pyrrol...)
Affinity DataIC50:  55nMAssay Description:In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent