BDBM410190 5-((2R,4S)-4-fluoro-2-(5-fluoro-2-methoxypyridin-3-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile ::US10370379, Compound 7::US11059827, Compound 7

SMILES COc1ncc(F)cc1[C@H]1C[C@H](F)CN1c1ccn2ncc(C#N)c2n1

InChI Key InChIKey=VHOLGUPBIVPOIB-GXTWGEPZSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 410190   

TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM410190(5-((2R,4S)-4-fluoro-2-(5-fluoro-2-methoxypyridin-3...)
Affinity DataIC50: <10nMAssay Description:In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM410190(5-((2R,4S)-4-fluoro-2-(5-fluoro-2-methoxypyridin-3...)
Affinity DataIC50: <100nMAssay Description:In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM410190(5-((2R,4S)-4-fluoro-2-(5-fluoro-2-methoxypyridin-3...)
Affinity DataIC50: <10nMAssay Description:Inhibition of NTRK1 in human KM12 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed