BDBM414074 (R)-6-(6-chloro-1H- pyrrolo[2,3-b]pyridin-4- yl)-7-methyl-4-((1S,5R)- 8-(methylsulfonyl)-8- azabicyclo[3.2.1]oct-2- en-3-yl)-5,6,7,8-tetra- hydropyrido[4,3-d]- pyrimidine::US10421765, Example 60::US10745420, Example 60

SMILES C[C@@H]1Cc2ncnc(C3=CC4CCC(C3)N4S(C)(=O)=O)c2CN1c1cc(Cl)nc2[nH]ccc12

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 414074   

TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Homo sapiens (Human))
Board of Regents, The University of Texas System

US Patent
LigandPNGBDBM414074((R)-6-(6-chloro-1H- pyrrolo[2,3-b]pyridin-4- yl)-7...)
Affinity DataIC50:  66nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Homo sapiens (Human))
Board of Regents, The University of Texas System

US Patent
LigandPNGBDBM414074((R)-6-(6-chloro-1H- pyrrolo[2,3-b]pyridin-4- yl)-7...)
Affinity DataIC50:  66nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent