BDBM414081 (S)-1-((R)-6-(6-chloro- 1H-pyrrolo[2,3-b]pyridin- 4-yl)-7-methyl-5,6,7,8- tetrahydropyrido[4,3-d]- pyrimidin-4-yl)-N- methylpiperidine-3- carboxamide::US10421765, Example 67::US10745420, Example 67

SMILES CNC(=O)[C@H]1CCCN(C1)c1ncnc2C[C@@H](C)N(Cc12)c1cc(Cl)nc2[nH]ccc12

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 414081   

TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Homo sapiens (Human))
Board of Regents, The University of Texas System

US Patent
LigandPNGBDBM414081((S)-1-((R)-6-(6-chloro- 1H-pyrrolo[2,3-b]pyridin- ...)
Affinity DataIC50:  140nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Homo sapiens (Human))
Board of Regents, The University of Texas System

US Patent
LigandPNGBDBM414081((S)-1-((R)-6-(6-chloro- 1H-pyrrolo[2,3-b]pyridin- ...)
Affinity DataIC50:  140nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent