BDBM414109 (R)-7-methyl-4-(1- (methylsulfonyl)piperidin- 4-yl)-6-(6-(2,2,2-tri- fluoroethoxy)-1H- pyrrolo[2,3-b]pyridin-4- yl)-5,6,7,8-tetrahydro- pyrido[4,3-d]pyrimidine::US10421765, Example 96::US10745420, Example 96

SMILES C[C@@H]1Cc2ncnc(C3CCN(CC3)S(C)(=O)=O)c2CN1c1cc(OCC(F)(F)F)nc2[nH]ccc12

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 414109   

TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Homo sapiens (Human))
Board of Regents, The University of Texas System

US Patent
LigandPNGBDBM414109((R)-7-methyl-4-(1- (methylsulfonyl)piperidin- 4-yl...)
Affinity DataIC50:  321nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Homo sapiens (Human))
Board of Regents, The University of Texas System

US Patent
LigandPNGBDBM414109((R)-7-methyl-4-(1- (methylsulfonyl)piperidin- 4-yl...)
Affinity DataIC50:  321nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent