BDBM4169 1,6-naphthyridin-2(1H)-one deriv. 7b::3-(2,6-Dichlorophenyl)-1-methyl-7-(methylamino)-1,6-naphthyridin-2(1H)-one::3-(2,6-dichlorophenyl)-1-methyl-7-(methylamino)-1,2-dihydro-1,6-naphthyridin-2-one

SMILES CNc1cc2n(C)c(=O)c(cc2cn1)-c1c(Cl)cccc1Cl

InChI Key InChIKey=MWTPPQWWCAVXIS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 4169   

TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
University of Auckland

LigandPNGBDBM4169(1,6-naphthyridin-2(1H)-one deriv. 7b | 3-(2,6-Dich...)
Affinity DataIC50:  8.00E+3nMpH: 7.0 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
University of Auckland

LigandPNGBDBM4169(1,6-naphthyridin-2(1H)-one deriv. 7b | 3-(2,6-Dich...)
Affinity DataIC50:  420nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
University of Auckland

LigandPNGBDBM4169(1,6-naphthyridin-2(1H)-one deriv. 7b | 3-(2,6-Dich...)
Affinity DataIC50:  210nMpH: 7.0 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed