BDBM422192 2-cyclopentyl-5-(4- cyclopropylbenzene- sulfonyl)-1-(2,6- dimethoxyphenyl)-6- hydroxy-1,4- dihydropyrimidin-4-one::US10508104, Example 86

SMILES COc1cccc(OC)c1-n1c(O)c(c(=O)nc1C1CCCC1)S(=O)(=O)c1ccc(cc1)C1CC1

InChI Key InChIKey=HPQYDENIDXYUIF-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 422192   

TargetApelin receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM422192(2-cyclopentyl-5-(4- cyclopropylbenzene- sulfonyl)-...)
Affinity DataEC50:  5nMAssay Description:HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetApelin receptor(Mus musculus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM422192(2-cyclopentyl-5-(4- cyclopropylbenzene- sulfonyl)-...)
Affinity DataEC50:  0.400nMAssay Description:Agonist activity at mouse APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetApelin receptor(Rattus norvegicus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM422192(2-cyclopentyl-5-(4- cyclopropylbenzene- sulfonyl)-...)
Affinity DataEC50:  1.5nMAssay Description:Agonist activity at rat APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetApelin receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM422192(2-cyclopentyl-5-(4- cyclopropylbenzene- sulfonyl)-...)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at human APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed