BDBM423496 US10508115, Compound Ib-15::US10508115, Compound Ib-17

SMILES CCCCOc1nc(N)c2nc(O)n(Cc3ccc(Oc4ccc(CNCC5CC5)cc4)nc3)c2n1

InChI Key InChIKey=AURJCCSZKJWPIV-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 423496   

TargetToll-like receptor 7(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM423496(US10508115, Compound Ib-15 | US10508115, Compound ...)
Affinity DataEC50:  1.10nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue™ TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-6(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM423496(US10508115, Compound Ib-15 | US10508115, Compound ...)
Affinity DataEC50:  5.11nMAssay Description:Compounds diluted in DMSO were transferred to individual wells of a Matrix Technologies clear, V-bottom 384-well plate using ECHO acoustic liquid han...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM423496(US10508115, Compound Ib-15 | US10508115, Compound ...)
Affinity DataEC50:  0.830nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue™ TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-6(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM423496(US10508115, Compound Ib-15 | US10508115, Compound ...)
Affinity DataEC50:  64.7nMAssay Description:Compounds diluted in DMSO were transferred to individual wells of a Matrix Technologies clear, V-bottom 384-well plate using ECHO acoustic liquid han...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent