BDBM424400 US10508120, Compound I-855::US10577373, Compound I-855::US11046698, Compound I-855

SMILES CNc1cc(nc2c(cnn12)C(=O)N[C@@H]1COC[C@@H]1O)-c1cn(CCN2CCOCC2)c2ncccc12

InChI Key InChIKey=JOSMVKNVUVTVOR-RTWAWAEBSA-N

Data  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 424400   

TargetNon-receptor tyrosine-protein kinase TYK2 [556-888](Homo sapiens (Human))
Nimbus Lakshimi

US Patent
LigandPNGBDBM424400(US10508120, Compound I-855 | US10577373, Compound ...)
Affinity DataKd:  5.5nMAssay Description:Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2 [556-888](Homo sapiens (Human))
Nimbus Lakshimi

US Patent
LigandPNGBDBM424400(US10508120, Compound I-855 | US10577373, Compound ...)
Affinity DataKd:  5.5nMAssay Description:Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2 [556-888](Homo sapiens (Human))
Nimbus Lakshimi

US Patent
LigandPNGBDBM424400(US10508120, Compound I-855 | US10577373, Compound ...)
Affinity DataKd:  5.5nMAssay Description:Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent