BDBM426250 5-[2-(4-Fluorophenyl)-7-(4-fluoro-1-piperidyl)pyrazolo[1,5-c]pyrimidin-::US10513523, Example 190

SMILES FC1CCN(CC1)c1nccc2c(c(nn12)-c1ccc(F)cc1)-c1ccc2NC(=O)Cc2c1

InChI Key InChIKey=GZFJUMACVQXRQE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 426250   

TargetGlutamate receptor 1/Voltage-dependent calcium channel gamma-2 subunit(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM426250(5-[2-(4-Fluorophenyl)-7-(4-fluoro-1-piperidyl)pyra...)
Affinity DataIC50:  5nMAssay Description:Negative allosteric modulation of recombinant human GluA1 flop isoform/TARPgamma2 expressed in HEK293 cells assessed as inhibition of glutamate-induc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM426250(5-[2-(4-Fluorophenyl)-7-(4-fluoro-1-piperidyl)pyra...)
Affinity DataIC50:  0.200nMAssay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent