BDBM428685 (R or S)-5-[9-ethyl-8-(2- methylpyrimidin-5-yl)-9H- purin-6-yl]-3-(3-methoxy- 3-methylazetidin-1-yl)-3- methyl-1,3-dihydro-2H- indol-2-one::US10544147, Compound 2-1::US10544147, Compound 2-2

SMILES CCn1c(nc2c(ncnc12)-c1ccc2NC(=O)C(C)(N3CC(C)(C3)OC)c2c1)-c1cnc(C)nc1

InChI Key InChIKey=GFTNPBJDAYSSNL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 428685   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM428685((R or S)-5-[9-ethyl-8-(2- methylpyrimidin-5-yl)-9H...)
Affinity DataIC50:  176nMAssay Description:The PI3-Kinase biochemical assays were developed to measure the intrinsic potency and compound dependent inhibition of the alpha, beta, delta, and ga...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM428685((R or S)-5-[9-ethyl-8-(2- methylpyrimidin-5-yl)-9H...)
Affinity DataIC50:  2nMAssay Description:The PI3-Kinase biochemical assays were developed to measure the intrinsic potency and compound dependent inhibition of the alpha, beta, delta, and ga...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent